Reading the first digit
1xx informational, 2xx success, 3xx redirection, 4xx the client did something wrong, 5xx the server did. When debugging: a 4xx means fix the request; a 5xx means look at server logs.
The ones worth memorizing
200, 201, 301, 302, 304, 400, 401, 403, 404, 429, 500, 502, 503 cover the overwhelming majority of everything you'll ever see in logs and API responses.